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We all have challenges. It is the way that we choose to perceive and respond to them that makes the difference. Watch The Woman Whose Legs Turned Black. Featured on Oprah's OWN and Disovery Health's Mystery Diagnosis TV Show.



PSA created to help patients, friends and families better understand and overcome cryoglobulinemia.
Thank you for caring and sharing!

Being diagnosed with a rare disease can be scary. Cryoglobulinemia is so rare that there are no statistics available on how many patients are affected.

The diagnosis of cryoglobulinemia depends on the presence of cryoglobulins in the blood and then searching for a possible underlying cause. The first cryoprecipitation phenomenon was attributed to Wintrobe and Buell, who in 1933, described a patient with signs and symptoms of hyperviscosity associated with multiple myeloma. In 1947, the “cold precipitable serum globulin” was assigned the term “cryoglobulin” by Lerner and Watson.

Cryoglobulinemia is the presence of abnormal proteins in the blood. These abnormal proteins become thick or gel-like when exposed to cold temperatures and stress. Cryoglobulinemia as a form of vasculitis can cause damage and inflammation of the blood vessels, which includes the veins, arteries and capillaries, throughout the body.


Cryoglobulinemia​ Vasculitis Organization (CVO) created this PSA in an effort to educate, encourage and increasing awareness. We hope you find help and hope through the information offered.


Dedicated volunteers developed CVO to help bring the Cryo community together. CVO's Facebook page is very helpful, active and is connecting people all over the world. If you would like to join the team of dedicated volunteers ​please contact us today.

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